Providing new scientific insights in the field of personalized medicine and the management of chronic pathologies in the archipelago is the purpose of an initiative that has benefited from the line of aid for applied R&D projects of the Government of the Canary Islands, managed by the Ministry of Universities, Science, Innovation and Culture (CUCIC) through the Canary Agency for Research, Innovation and Information Society (ACIISI).
This is the project 'Impact of non-alcoholic fatty liver disease on graft inflammation and atheromatosis after kidney transplantation', a research led by the Canary Islands Health Research Institute Foundation (FIISC) that seeks to deepen the inflammatory pathogenic mechanisms that compromise the health of transplanted patients.
Medical innovation against chronic graft deterioration
Kidney transplantation (KT) currently represents the therapy of choice and of greatest effectiveness for people suffering from chronic kidney disease (CKD). However, the long-term survival of these treatments continues to face significant medical challenges: it is estimated that around 50% of grafts are lost within ten years of the procedure, either due to the patient's death or due to the appearance of chronic graft dysfunction (CGD).
Faced with this scenario, the FIISC study will explore in a pioneering way how non-alcoholic fatty liver disease influences the inflammatory processes of the transplanted organ and the development of atheromatosis (fat accumulation in the arteries). The project's results aim to open new avenues to improve clinical prognosis, refine postoperative follow-up, and combat one of the main causes of water graft loss.
Budgetary support and strategic fit in the islands
In the scientific and technical evaluation section, the FIISC proposal obtained a distinguished rating of 76.07 points, which has made it possible to secure an institutional subsidy of 129,786.72 euros for its development.
By its nature and objectives, research has a notable socioeconomic impact in the Canary Islands, as it directly affects a patient population that usually presents a high burden of comorbidity and requires an intensive use of the archipelago's healthcare resources. The project responds precisely to the sectoral area of Welfare and Health, and aligns with the Canary Islands Smart Specialisation Strategy (RIS3 expanded), promoting the generation of cutting-edge biomedical knowledge in the region.
The study is integrated within the 17 projects that make up this regional call for applied R&D —with a total endowment of more than 2.5 million euros— and is co-financed by the European Union through the European Regional Development Fund (ERDF) within the ERDF Canary Islands Programme 2021-2027. With this boost, the Canary Islands research fabric consolidates its competitiveness and its transfer capabilities in the public health sector.
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